Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival
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چکیده
منابع مشابه
Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.
Extensive apoptosis of leukocytes during sepsis and endotoxic shock constitutes an important mechanism linked to the excessive mortality associated with these disorders. Caspase inhibitors confer protection from endotoxin-induced lymphocyte apoptosis and improve survival, but it is not clear which caspases mediate lipopolysaccharide (LPS)-induced lymphocyte apoptosis and mortality. We report he...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2008-09-178038